Archive | November, 2013

RNA Interference: Another Bio-mechanism Affected By EMF’s

Posted on 01 November 2013 by admin

RNA-InterferenceWhat is RNA Interference?

RNA interference (RNAi) also called post transcriptional gene silencing (PTGS), is a biological process in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules. Historically, it was known by other names, including co-suppressionpost transcriptional gene silencing (PTGS), and quelling. Only after these apparently unrelated processes were fully understood did it become clear that they all described the RNAi phenomenon. In 2006, Andrew Fire and Craig C. Mello shared the Nobel Prize in Physiology or Medicine for their work on RNA interference in the nematode worm C. elegans, which they published in 1998.

What does this mean to the EMF research world?

There are more and more studies world wide piling up showing many different health effects, both good and bad, from EMF sources in our environment. One that seems to be a key to the research is RNA Interference. This process actually silences certain genes so that cells do not function properly. It is a very complex and still being understood matter but could explain one of the many health effects of the damaging effects of EMF’s.

Living near large power lines, using cell phones, and more sources are all known to affect cells in negative ways by disrupting biochemistry. If EMF’s damage DNA enough it could cause RNA Interference which would cause cells to malfunction, die off, or accelerate growth such like in cancer.

In a paper published in the January 1990 issue of Radiation Research (121. pp.38-45). Dr. Stephen Cleary reported that RF/MW radiation had pronounced effects on the DNA and RNA synthesis of glioma cells, as measured by the incorporation of thymidine and uridine-genetic building blocks.

Five days after a two-hour exposure to radio frequency and microwave (RF/MW) radiation, human brain tumor cells continued to proliferate at an abnormally high rate. At higher
levels, however, the radiation suppressed cell growth. The researchers found highly statistically significant enhancement at specific absorption rates (SARs) of 5 or 25 W/ Kg. At higher SARs, cell growth was suppressed. Essentially the same effects were obtained for exposures to unmodulated 27 MHz and 2450 MHz radiation. The cells were kept at a constant temperature during ex- posure, allowing the authors to conclude that the “effects were not induced indirectly by heating.”

This indicates that the exposure of these regularly experienced frequencies may be one of many reason that cells do not operate properly when around them. Even though this is more than likely only one of many different biological effects that have been noticed, using this knowledge to create devices to target living things could prove to be used in weaponry.  A silent yet potent device such as these may already be near your home, school, or workplace in the forms of power lines, cell phones, radio towers, and more.

This same research may help understand how we can combat the illnesses caused by them as well, but at this point the medical industry is pursuing pills from pharmaceuticals that chemically perform these gene silencing  functions.

Is there a positive effect of RNA Interference? Can it help fight cancer?

Pennsylvania State University Researchers Zero in on Small Interference RNAs (siRNAs) – NewsRX Health Articles

Investigators discuss new findings in Small Interference RNAs (siRNAs). According to news reporting from Hershey, Pennsylvania, by NewsRx journalists, research stated, “CD47 is a ‘self marker’ that is usually overexpressed on the surface of cancer cells to enable them to escape immunosurveillance. Recognition of CD47 by its receptor, signal regulatory protein alpha (SIRP alpha), which is expressed in the macrophages, inhibits phagocytic destruction of cancer cells by the macrophages.”

The news correspondents obtained a quote from the research from Pennsylvania State University, “In this study, we have first shown that clinical isolates of human melanoma significantly upregulate CD47, possibly as a mechanism to defend themselves against the macrophages. We then exploited RNA interference (RNAi) technology to test the hypothesis that knocking down CD47 in the tumor cells will render them targets for macrophage destruction; hence, creating a novel anti-cancer therapy.

Anti-CD47 siRNA was encapsulated in a liposome-protamine-hyaluronic acid (LPH) nanoparticle (NP) formulation to address the challenge of targeted delivery of siRNA-based therapeutics in vivo. Efficient silencing of CD47 in tumor tissues with systemic administration of LPH(CD47) also significantly inhibited the growth of melanoma tumors. In a lung metastasis model, LPH(CD47) efficiently inhibited lung metastasis to about 27% of the untreated control. Moreover, no hematopoietic toxicity was observed in the animals that received multiple doses of LPH(CD47).” The research concluded: “Our findings indicate CD47 as a potential prognostic marker for melanoma development as well as a target for therapeutic intervention with RNAi-based nanomedicines.”

 

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Does Magnetic Therapy Work?

Posted on 01 November 2013 by admin

Magnetic-Therapy

Magnetic therapy is an alternative medical practice that uses static magnets — usually in the form of bracelets, rings, wraps and shoe inserts — to alleviate pain and other health concerns. The medical community largely considers these magnetic products to be based on pseudoscience and devoid of any therapeutic value beyond the placebo effect.

Indeed, many well-conducted studies over the past three decades have shown that static magnetic devices offer no more or no less benefit than sham devices devoid of a magnet, in essence demonstrating the placebo effect magnets have on their users.

Nevertheless, magnetic therapy remains extremely popular, with sales of therapeutic magnets greater than $300 million in the United States alone, according to various estimates.

How it’s supposed to work
As with many forms of alternative medicine, magnetic therapy is based on reasonably sounding yet unscientific principles.

Magnetic therapy dates back millennia, as traditional healers attributed healing properties to the mysterious phenomenon of magnetic lodestones. Many such healers believed, in earnest, that the stones could draw disease from the body. Today, the most common, purported mechanism of action is that the magnet improves blood flow of the underlying tissue.

This sounds plausible because blood contains iron, and magnets attract iron. But iron in blood is bound to hemoglobin and actually is no longer ferromagnetic (that permanent kind of magnetism that keeps magnets on a refrigerator, for example). Instead, blood is diamagnetic when carrying oxygen and paramagnetic when not carrying oxygen. In either case, the attraction is weak and not permanent.

This is a good thing. If blood was ferromagnetic, you would essentially blow up when undergoing an MRI scan, in which the magnets used are thousands of times more powerful than those incorporated into magnetic bracelets and the like.

Regardless, the magnets used for this kind of therapy have magnetic fields that are generally too weak to penetrate your skin. You can test this by observing the weak interaction between a magnetic shoe insert and a paperclip when separated by a sock. Human skin is about 3 millimeters deep, thicker than some socks.

A second mechanism of action claimed by some proponents of magnetic therapy is that the magnets somehow alter the body’s electromagnetic energy balance. The problem here is that there’s no recognized concept among most physicists and medical doctors called electromagnetic energy balance — or life-flow, or energy flow, or chi.

Life flow or no, safety studies for powerful MRI scans reveal no discernable effect by magnets on the body.

What the studies say
Implausible physics aside, scientific studies on human subjects have failed to show the efficacy of using magnets to treat pain or joint and muscle stiffness. One of the largest studies was published in 2007 in the Canadian Medical Association Journal — a systematic review of numerous previous studies on static magnets.

While some smaller studies in this review reported therapeutic value, larger studies did not. The researchers concluded: “The evidence does not support the use of static magnets for pain relief, and therefore magnets cannot be recommended as an effective treatment.”

One positive result often cited by magnetic therapy advocates is a 1997 study from Baylor College of Medicine, titled “Response of pain to static magnetic fields in postpolio patients: a double-blind pilot study.”

This study, led by Carlos Vallbona, reported “significant and prompt relief of pain in postpolio subjects” through the use of a 300-500 gauss magnet (about 10 times stronger than a refrigerator magnet) for 45 minutes on the affected area of 50 patients in pain.

This was a respected, albeit small, study by a respected research group. Rarely noted, however, is the fact that this was only a pilot study. Vallbona never duplicated the results in a larger study and, in fact, never published again on the topic.

Magnets that do work
Magnetic therapy should not be confused with pulsed electromagnetic field therapy (PEMFT), which is used for bone healing and, more recently, for depression.

In PEMFT, instead of a relatively weak static magnet, doctors use a special machine to apply pulses of intense electromagnetic energy to the affected area to initiate healing. For bone fractures, the pulses induce electrical signals at a subcellular level that stimulate chemicals in the cells to repair damaged tissue.

This therapy dates back to the early 1900s and Nikola Tesla, one of the pioneers in the use of electricity. In the United States, the technique was first used on animals, such as racehorses with broken bones, before being deemed safe for humans in the 1970s.

With numerous supportive studies published, the medical establishment now widely accepts PEMFT for certain types of bone fracture repair. PEMFT for pain management, wound healing and depression appears promising, according to medical studies, but this use of PEMFT is generally less accepted by medical practitioners.

By Christopher Wanjek, LiveScience Contributor
This original article posting can be found here: www.Livescience.com

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